白介素17对革兰阴性杆菌肺炎炎症调节作用的研究进展

Prowess in researches about inflammatory regulation of interleukin-17 in gram-negative bacterial pneumonia

白介素（interleukin，IL）17是目前新发现的主要由CD4^＋6记忆T细胞、单核细胞分泌的一种前炎性细胞因子。其在细胞增殖分化、生物因子转录与表达及免疫调节方面发挥着重要的作用，与多种炎症尤其是革兰阴性杆菌肺炎的炎症过程密切相关。IL-6、转化生长因子β1、IL-23共同作用激活辅助性17细胞的转录因子信号转导和转录激活因子3、孤儿细胞核受体γt产生IL-17，从而招募中性粒细胞聚集，促进多种细胞因子释放，提高革兰阴性杆菌的清除率，对革兰阴性杆菌肺炎有重要的防御作用。

Interleukin（IL）-17 is a newly founded proinflammatory eytokine,produced by CD4^＋ T cell and lymphomonocyte. It has significant functions in cell multiplication, biological factor transcription and expression,immunity regulation. It is related with inflammation disease, especially gram-negative bacterial pneumonia. IL-6, transforming growth factor-β1 , in combination with IL-23, induced signal transducer and activator of transcription 3 and retinoid-related orphan receptor γt, transcription factor of T helpl 7, to release IL-17,recruit neutrophil, release cytokines and enchance gram-negative bacterial clearance. Local production of IL-17 is a significant factor in effective host defense against gram-negative bacterial pneumonia.