核因子κB与肺炎治疗的最新进展

New development of pneumonia therapy through nuclear factor-kappaB

肺部急、慢性炎症是肺部多种疾病的共同病理变化，炎症介质的过度释放对肺造成损害。核因子κB（nuclear factor kappaB，NF—κB）存在于几乎所有细胞中，参与介导了免疫应答、病毒复制、细胞凋亡和增殖的多种基因的表达调控，尤其在调节炎症反应相关基因中起关键作用。本文对NF-κB在肺炎发生、发展过程中所扮演的角色及以NF—κB为靶点治疗肺炎的进展作一综述。

Acute or chronic inflammation is a common pathological course in many lung diseases. Excessive inflammation factors will injure lung. Nuclear factor-kappaB（NF-κB） exists in almost all kinds of cells and plays an important roles in regulating the expression of plenty of genes, such as virus multiplication,multiplication or withered of cells, especially the expression of inflammation gene. The article discusses the role of NF-κB in the development of pneumonia and how to treat pneumonia through NF-κB.