摘要
在抗结核治疗策略中，异烟肼是最重要的一线药物。在过去50年的抗结核治疗中，异烟肼发挥了非常重要的作用，而耐异烟肼结核菌的出现使这种效果减弱。本文从异烟肼的抗结核机制入手，对异烟肼耐药的分子机制作一综述。
Isoniazid is one of the most important first-line drugs of anti-tuberculosis strategy. In the past 50 years, isoniazid played a very important role in anti-tuberculosis treatment. However, with the emergence of isoniazid-resistant Mycobacterium tuberculosis, the efficacy is decreasing. Herein, this article discusses the mechanism of isoniazid action against Mycobacterium tuberculosis, and reviews the molecular mechanism of isoniazid resistance in Mycobacterium tuberculosis.
出处
《国际呼吸杂志》
2009年第4期234-237,共4页
International Journal of Respiration
关键词
异烟肼
结核分枝杆菌
耐药性
Isoniazid
Myeobacterium tuberculosis
Drug-resistant
