慢性肾功能衰竭药效学研究的设计和方法

Methodology of Pharmacodynamic Study on Chronic Renal Failure

从医学基础、原理到方法综述了对慢性肾功能衰竭（ＣＲＦ）的药效学研究的设计和方法，着重介绍了大鼠腺嘌呤ＣＲＦ模型，大鼠５／６肾切除ＣＲＦ模型。

This paper deals with a pharmacodynamic study on the chronic renal failur(CRF),The model of adenineinduced CRF in rats,the CRF model caused by 5/6 nephrectomy in rats and the model of mouse with sequential electrocoagulation of the right renal cortex and the left nephrectomy induced CRF have been especially introduced.