食管下段收缩性与血浆环磷酸腺苷浓度的关系

The relationship between lower esophageal contractility and plasma concentration of cyclic AMP

目的:研究诱发性食管下段收缩性(PLEC)与应激反应的关系。方法:对32例择期手术成人在0.2%～2.4%不同呼气末异氟醚浓度(ETiso)时测定PLEC波幅和血浆环磷酸腺苷(cAMP)含量314次,分析后二者的相关性;同时分析cMAP、PLEC、与ETiso间的相互关系。结果:PLEC与cAPM呈正相关(r=0.1717.P<0.05);cAMP与ETiso呈负相关(r=-0.2670,P<0.05);ETiso与PLEC呈负相关(r=-0.7990,P<0.05)。结论:异氟醚麻醉下术中PLEC与cAMP相关系数小,仅能反映cAMP大致的变化趋势;异氟醚对术中血浆cAMP水乎的上升仅有一定限度的抑制作用;PLEC与ETiso相关密切,可作为判断异氟醚麻醉深度的指标之一。

The relationship between provoked lower esophageal contractility (PLEC) and surgical stress response was studied. Method: 314 sets of measurements of PLEC and plasma concentration of cyclic AMP (cAMP). as a parameter for stress response,were collected in 32 adult patients undergoing elective surgical operations with isoflurane anesthesia. and then the relationships between (1) PLEC and cAMP. (2)cAMP and end-tidal isoflurane concentration (ETiso), and (3) ETiso and PLEC were identified. Result: The significant correlations were found between (1) PLEC and cAMP (r=0.1717, P<0.05), (2) cAMP and ETiso (r=-0.2670, P<0.05);(3)ETiso and PLEC (r=-0.7990. P<0.05). Conclusion: (1)PLEC may be helpful to evaluate changes of plasma cAMP concentra tion during surgery; (2)plasma cAMP response may be partially inhibited by isoflurane; (3)PLEC monitoring is useful in assessing depth of isoflurane anesthesia.