摘要
目的:探讨异丙酚对单肺通气(OLV)时缺氧性肺血管收缩(HPV)、肺内分流(Qs/Qt)的影响。方法:观察组用异丙酚6~12mg·kg-1·h-1静注,对照组用不抑制HPV、对Qs/Qt无影响的普鲁卡因40~60mg·kg-1·h-1静滴。观察两组OLV不同时期Qs/Qt、PaO2、PvO2、PaCO2和pH值变化。结果:OLV时两组病人Qs/Qt明显升高,PaO2明显下降(P<0.01),PvO2、pH、PaCO2无明显变化。OLV时,两组病人的Qs/Qt和PaO2组内不同时值或组间同时值比较均无显著差异(P>0.05)。结论:异丙酚不抑制OLV时HPV,对Qs/Qt无明显影响,OLV时无低氧、高碳酸血症和酸碱失衡。
Objective: This study eveluates the effect of propofol on hypoxic pulmonary vasoconstriction (HPV) and intrapulmonary shunt(s/t) during one lung ventilation(OLV). Methods: 20 patients sheduled for thoracic operation were randomly divided into propofol (group Ⅰ) and control (group Ⅱ) groups. The anesthesia was maintained with an infusion of either propofol (6~12mg·kg-1·h-1) in group Ⅰ or procaine (40~60mg·kg-1·h-1) in group Ⅱ. The arterial and mixed venous blood were taken for blood gas analysis. The Qs/Qt was calculated. Results: s/t increased, PaO2 decreased significantly during OLV compared with that during TLV in two groups (P<001). The differences between two groups in s/t and PaO2 were insignificant at all sampling points. Conclusion: Propofol does not neither inhibit HPV nor influence on s/t during OLV.
出处
《临床麻醉学杂志》
CAS
CSCD
1998年第2期87-88,共2页
Journal of Clinical Anesthesiology
关键词
异丙酚
单肺通气
肺内分流
Propofol One lung ventilation HPV Intrapulmonary shunt