复发性口疮患者HSV-1的检测及其抗病毒治疗观察

Detection of HSV-1 and Antivirus Treatment for Patients with Recurrent Oral Ulcers

目的：为了研究单纯疱疹病毒Ⅰ型与复发性口疮的关系。方法：采用PCR技术检测复发性口疮患者（ROU）损害区和健康对照者口腔粘膜脱落细胞的HSV－1DNA，然后对HSV－1DNA阳性和阴性患者用无环鸟苷作抗病毒治疗，并观察半年。结果：ROU患者HSV－1DNA的检出率为26.7%（16/60），对照组为6．7%（2／30），两者之间有高度显著性差异（P＜0．005）。HSV-1DNA阳性者与阴性者抗病毒治疗有效率分别是93．75％和13．6%（P＜0．005）。结论：HSV-1与部分ROU有关，对HSV－1阳性患者宜作抗病毒治疗。

Objective : To investigate the association between HSV - 1 and recurrent oral ulcers (ROU). Methods : ThePCR was used to dstect HSV- 1 DNA in scrape specimens of oral ulcerative lesions from 60 patients with recurrent oral ulcersand in smeared epithelium from 30 health controls. And then all of patients were treated with Acyclovir and followed up for sixmonths. Results: the Patients and the controls exhibited significant difference in positive rate of HSV -1 DNA, 26 .7% (16/60)of the patients was positive for HSV- 1 DNA, wheras only 6.7%(2/30) of controls was positive (P < 0.005). The effectiverate of treatment for positive patients was 93.75%, and that of treatment for negative patients was 13 .63% (P <0. 025). Con-cluslons:There is a correlation between HSV - 1 and some patients with ROU. And patiens who were positive for HSV - 1 DNAshould be treated with antivirus drug.