烟台地区肺炎链球菌的耐药性检测

Surveillance of antimicrobial resistance of streptococcus pneumoniae in Yantai area

目的监测烟台地区肺炎链球菌的耐药性,为临床合理应用抗菌药物提供理论依据。方法收集烟台地区部分医院临床分离的肺炎链球菌,用E-试验、K-B法检测此菌对青霉素等10种抗菌药物的敏感度。结果102株肺炎链球菌中71株(70%)对青霉素不敏感。未检出对头孢噻肟、阿莫西林、左旋氧氟沙星和万古霉素耐药的菌株。对克林霉素、红霉素、四环素和复方新诺明耐药率很高,分别为97%、100%、100%和96%。结论烟台地区青霉素不敏感肺炎链球菌检出率高,对大环内酯类药物耐药状况极为严峻。

Objective To monitor the antimicrobial resistance of streptococcus pneumonlae m Yantai area so as to provide theoretical basis for rational use of antibiotics. Methods The clinical streptococcus pneumoniae isolates were collected from some hospitals in Yantai area. E-test and K-B disk diffusion method were used to determine the susceptibility of streptococcus pneumoniae to 10 anti- microbial agents. Results Sevent-one streptococcus pneumoniae isolates（71/102, 70%） were insensi-tive to penicillin. None of cefotaxime-, amoxicillin-, levofloxacin-, and vancomycin-resistant strains was found. The resistance rate of streptococcus ＂pneumoniae was relatively highly resistant to clindamycin, erythromycin, tetracycline and TMP-SMZ, 97%, 100%, 100% and 96% respectively. Conclusion Penicillin non-susceptible streptococcus pneumoniae is highly prevalent in Yantai area. The situation is serious about macrolide-resistance of streptococcus pneumoniae.