哮喘患儿血清ICAM-1、IL-4和IgE的相关性研究:附33例报告

Study on mutual relativity of scrum intercellular adhesive molecule-1, interleukin-4 and IgE levels in children with bronchial asthma: A report of 33 cases

测定33例哮喘患儿和10例健康儿血液细胞间粘附因子(ICAM-1)、IL-4和IgE。结果:哮喘发作组ICAM-1、IL-4和IgE分别为527.79±443.22ng/ml、245.99±116.86pg/ml和1270.90±1299.87U/ml;哮喘缓解组分别为433.51±377.38ng/ml、192.98±112.25pg/ml和362.62±231.99U/ml;健康对照组分别为214.17±78.61ng/ml、131.472±36.35pg/ml和133.09±118.99U/ml。发作组与对照组三指标相比有显著性差异;发作组与缓解组及缓解组与对照组之间仅IgE有显著性差异。各组三指标之间除发作组IgE与IL-4呈显著正相关外,余均无显著性相关。提示ICAM-1、IL-4和总IgE升高是哮喘过敏性炎症的表现;研究ICAM-1、IL-4的拮抗剂对哮喘治疗有积极意义。

In this paper, serum ICAM-1. IL-4 and IgE levels have been separately determined during different disease courses in 33 children with bronchial asthma and 10 norrnal healthy children. Hence, the results were, through statistical management, respectively obtained as folows: ICAM-1 527. 79 ± 443. 22ng/ml, IL-4 245. 99± 116. 86pg/ml, and IgE 1270. 90 ± 1299. 87U/ml during acute attack period, 433. 51 ± 377. 38ng/ml, 192. 98 ± 112. 25pg/ml and 362. 62 ± 231- 99U/ml during interval period; and 214. 17±78. 61ng/ml, 131. 472±36. 35pg/ml and 133. 09±118. 99U/ml in normal healthy children. As a result, it was clearly found that there was a very significant difference in all these 3 parameters between acute attack and normal control groups; and, otherwise, a significant difference could be only found in IgE level between acute attack and interval groups as well as between interval and normal control groups. Moreover, no significant relativity could be discovered among these 3 parameters in each group, except that there was a positive relativity between IgE and IL-4 levels in acute attack group. As described above, the authors concluded that elevated ICAM-1, IL-4 and IgE levels might be the pathophysiological manifestation of allergic inflammation of bronchial asthma and, therefore, it seems necessary to search for the antagonists against these 3 factors for the treatment of bronchial asthma.