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局麻药骨骼肌毒性作用的研究与临床意义 被引量：1

The study and clinical significance of local anesthetic myotoxicity
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摘要 最新研究证实，局麻药（locae anesthetic，LA）可导致骨骼肌损伤，甚至引起肌肉坏死，临床上使用的LA均存在骨骼肌毒性，因此将其对骨骼肌的损害视为局麻药的潜在并发症，但在临床上相关病例却很少见。现将近来国外对LA骨骼肌毒性的研究进展综述如下。 A lot of studies revealed that the local anesthetic may cause the degeneration of striated muscle sarcoplasmic reticulum and myocyte edema, even necrosis. All clinically used local anesthetics are myotoxic, with a drug-specific and dose-dependent rate of myotoxicity. We have to see local anesthetic myotoxicity as a potential complication. The molecular mechanism of local anesthetic myotoxicity are still not completely revealed. This articale reviews the recent related myotoxicity studies as follows.
作者 马冬梅 郑宏
机构地区 新疆维吾尔自治区人民医院麻醉科 新疆医科大学第一附属医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2009年第1期67-69,共3页 International Journal of Anesthesiology and Resuscitation
关键词 局麻药 骨骼肌毒性 诊断 预防措施 Local anesthetic Myotoxicity
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献13

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二级参考文献31

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共引文献33

同被引文献3

  • 1BartakovaV,Antalovska Z.Postupa J,et al.Experimental and clinical experiences with thelocal anesthetic ultracaine DS[J]. Dtsch Zahnarztl Z ,1987,42(11):973-977.
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  • 3赵燕平,马绪臣.疼痛的性别差异[J].中华口腔医学杂志,2002,37(4):312-314. 被引量：40

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国际麻醉学与复苏杂志
2009年 第1期

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