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再生障碍性贫血患儿骨髓间充质干细胞基因表达谱及成纤维细胞生长因子表达 被引量：2

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摘要 再生障碍性贫血（aplastic anemia，AA）是多种病因导致的以骨髓衰竭伴全血细胞减少为特征的疾病，目前认为免疫紊乱与其发病有关，具体机制还不清楚。间充质干细胞（mesenchymal stem cells，MSCs）具有免疫调节功能，在维持骨髓微环境稳定方面起着重要作用。Bacigalupoa等发现重型AA患者骨髓间充质干细胞对淋巴细胞的抑制作用减弱，从而认为间充质干细胞功能异常可能与AA的免疫紊乱有关。我们用功能分类芯片技术，
作者 蒋莎义 谢晓恬 周吉吉 石苇 邵越霞 周晓迅 匡寒琴 林洁靓
机构地区 上海同济大学附属同济医院儿科
出处 《中华儿科杂志》 CAS CSCD 北大核心 2009年第3期218-220,共3页 Chinese Journal of Pediatrics
基金 上海市卫生局资助项目（2006091）
关键词 骨髓间充质干细胞 再生障碍性贫血 成纤维细胞生长 基因表达谱 因子表达 患儿 全血细胞减少 免疫调节功能
分类号 R686 [医药卫生—骨科学]
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参考文献15

  • 1Bacigalupoa A, Vallea M, Podesta'a M, et al. T-cell suppression mediated by Mesenchymal stem cells is deficient in patients with severe aplastic anemia. Experimental Hematology, 2005, 33: 819 -827.
  • 2杨崇礼. 再生障碍性贫血. 见:陈敏章. 中华内科学[M]. 北京:人民卫生出版社,1999.2681-2685.
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二级参考文献12

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共引文献17

同被引文献26

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中华儿科杂志
2009年 第3期

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