PTTG和p53在非小细胞肺癌中的表达及其意义

Expression of PTTG and p53 gene in non-small cell lung carcinoma and its significance

目的:探讨非小细胞肺癌(NSCLC)组织中垂体肿瘤转化基因(PTTG)和p53的表达及其与NSCLC发生、发展之间的关系。方法:用免疫组化法测定61例NSCLC手术切除的癌组织标本及20例正常肺组织中PTTG、p53的表达。结果:NSCLC组织中PTTG、p53的表达率分别为68.85%和73.77%,明显高于正常肺组织的15.00%和10.00%(P均<0.01);在NSCLC不同组织学类型间,其表达率差异无统计学意义(P>0.05);在NSCLC不同分化程度之间,其表达率差异有统计学意义(P<0.05);在NSCLC是否伴淋巴结转移之间,其表达率差异亦有统计学意义(P<0.05)。PTTG与p53的表达率呈显著正相关(P<0.05)。结论:PTTG、p53在NSCLC组织中有较高的表达,有可能作为评估预后、指导治疗的参考指标。

Objective：To investigate the relationship between the expression of pituitary tumor-transforming gene （PTTG）and p53 and their roles in occuranee and development of non-small cell lung carcinoma. Methods：The expression of PTTG and p53 was detected immunohistochemistrically in 61 cases of non-small cell lung carcinoma and 20 cases of normal lung tissue. Results：There was an extensive expression of PTTG and p53 in tumor cell （ P 〈 0. 01 ） ; the difference was not found in groups of histomorpbology （ P 〉 0. 05 ）. The expression of PTTG and p53 in tumor cell was both correlated with differentiated degrees of lung cancer（ P 〈 0. 05 ）. In non-small cell lung carcinoma with lymph node metastasis, there was a significant difference （ P 〈 0. 05 ）. The positive expression of PTTG and p53 in non-small cell lung carcinoma had a striking positive correlation respectively（P 〈0. 05 ）. Conclusion：The results indicate that PTTG and p53 participate in occurrence and development of non-small cell lung carcinoma, and it may be the index of the prognosis appraisal and the therapeutic guidance.