子宫内膜癌雌激素非基因转录效应研究进展
被引量：1
摘要
子宫内膜癌是一种雌激素依赖性肿瘤，其发生、发展与高雌激素水平密切相关。1983年，Bokhman提出，根据发病机制，子宫内膜癌分为Ⅰ型即雌激素依赖型和Ⅱ型即非雌激素依赖型，其中Ⅰ型子宫内膜癌占70％～80％。雌激素发挥其生物学效应主要是通过结合细胞核内特异性的受体（即核受体），但Pietras和Szego提出，细胞膜也存在雌激素的结合部位（即膜受体），而膜受体的研究也只在近10年才有所进展。雌激素与受体结合后通过两条途径发挥其生物学作用。与核受体结合发挥基因转录效应，
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2009年第2期156-157,共2页
Chinese Journal of Obstetrics and Gynecology
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同被引文献21
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