藏族全面性强直阵挛性癫癎患者生活质量及其影响因素的调查

Survey of quality of life and its influenced factors in Tibetan patients with generalized tonic clonic epilepsy

目的调查藏族地区全面性强直阵挛性癫癎患者生活质量及其影响因素。方法应用癫癎患者生活质量评定量表-31(QOLIE-31)对126例确诊为全面性强直阵挛性癫癎的藏族患者进行生活质量评定,并对影响其生活质量的因素进行分析。结果QOLIE-31总评分为(48.58±17.29)分,分项中对发作担忧评分最低[(32.92±22.97)分],药物影响的评分最高[(77.11±20.98)分]。单因素分析显示:不同性别、职业、婚姻状况、年龄、文化程度的生活质量评分差异有统计学意义(均P<0.05);而不同发作频率、治疗与否评分差异无统计学意义。多因素分析表明,年龄、起病年龄、职业、文化程度、经济状况、发作次数是影响藏族全面性强直阵挛性癫癎患者生活质量的因素(均P<0.05);其中年龄、职业影响生活质量多个方面,而病程、婚姻状况、性别不是影响因素。结论藏族全面性强直阵挛性癫癎患者的生活质量差;职业、经济状况、文化程度、年龄、起病年龄、发作频率是影响生活质量的因素;年龄、职业影响生活质量的多个方面。

Objective To investigale the quality of life （QOL） and its influenced factors in Tibetan patients with generalized tonic clonic epilepsy. Methods QOL of 126 definit diagnosed Tibetan patients with generalized tonic clonic epilepsy were measured with the QOL in Epilepsy Inventory-31 （QOLIE-31）. The influenced factors of QOL were analysed. Results The total score of QOLIE-31 was 48.58±17.29; the lowest subcomponent score was 32.92±22.97 for Seizure Worry ; the highest was 77. 11 ±20. 98 for Medication Effects. Single factor analysis results were indicated that the scores of QOL between the different gender, occupation, marital status age, education were remarkable difference （all P〈0.05 ）. But between the different seizure frequency and receiving or no treatment were no singnificantly difference. Mnlti-factors analysis results were indicanted that age, age of epilepsy onset, occupation, education, economic status, and seizure frequency were the influenced factors of QOL （ all P 〈 0. 05 ）. Among them, the age and occupation were the factors influenced many aspects of QOL; but the course of disease, marital status and gender were not the influence factors of QOL. Conclusions The QOL of Tibetan patients with generalized, tonic clonic epilepsy are poor. The occupation, economic status, education, age, age of epilepsy onset and seizure frequency are the influenced factors of patients QOL. Age and occupation are its factors influenced many aspects of QOL.