2型糖尿病患者血清MMP-9、CRP与下肢血管病变的关系

Association of serum matrix metalloproteinase-9 levels and C-reactive protein with peripheral vascular disease of lower limbs in type 2 diabetes mellitas

对2型糖尿病患者行下肢血管B超检查，并比较血清基质金属蛋白酶9（MMP-9）及高敏c反应蛋白（hsCRP）水平间的关系。单纯2型糖尿病及经B超提示伴下肢血管病变患者均有不同程度的MMP-9及hsCRP升高，病变程度与hsCRP、MMP-9呈正相关，血清MMP-9水平与hsCRP呈正相关。

Serum matrix metalloproteinase-9 （ MMP-9）, hypersensitive C-reactive protein （hsCRP） and other clinical parameters were measured in patients with types 2 diabetes mellitu （with or without angiopathy of lower limbs）. The serum levels of MMP-9 and hsCRP were higher in type 2 diabetic patients and those with angiopathy by Doppler uhrasonography than those in normal controls. The change of serum MMP-9 was positively correlated with the level of hsCRP. The extent of angiopathy was correlated positively with both hsCRP and MMP-9.