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转染甲状腺钠／碘同向转运体的卵巢癌^99mTcO4^-显像及^131I治疗

Study on hNIS mediated transferring gene ^99mTcO4^- imaging and ^131I treatment in xenografted ovarian cancer
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摘要 目的通过观察^131I对转染人甲状腺钠／碘同向转运体（hNIS）的卵巢癌的治疗作用，为最终实现^131I治疗非甲状腺肿瘤提供理论依据。方法应用hNIS基因全长转染人卵巢癌细胞系，建立裸鼠卵巢癌荷瘤模型，在整体水平研究hNIS转染后介导的卵巢癌移植瘤^99mTcO4^-显像和^131I的治疗作用。结果转染hNIS基因后，原本不摄碘的卵巢癌可以应用^99mTcO4^-显像，并且在^131I作用下，肿瘤体积有所缩小。结论^131I对转染hNIS基因的卵巢癌移植瘤增殖具有较强的抑制作用。 Objective To establish radioiodine therapy in nonthyroid tumor and to investigate ^131I treatment effect on xenografted ovarian cancer. Methods Based on previous test, xenografted ovarian cancer nude model were established in nude mice. The effects of radioactive isotope ^99mTcO4^- imaging and radioiodine ^131I treatment on xenografted ovarian cancer in vivo were investigated. Results After transferring human sodium/iodide symporter （hNIS） gene, the xenografted ovarian cancer in nude mice was imaged by isotope ^99mTcO4^-. Moreover, ^131I exerted inhibitory effect on the proliferative activity. Conclusion After the transfection of hNIS gene, ^131I has inhibitory effect on proliferative activity of xenografted ovarian cancer. Metab, 2009,25：83-86）
作者 崔景秋 方佩华 李宁 冯凭 谭健
机构地区 天津医科大学总医院代谢病科 天津医科大学总医院核医学科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2009年第1期83-86,共4页 Chinese Journal of Endocrinology and Metabolism
基金 天津市卫生局科技基金（04K233）
关键词 甲状腺钠/碘同向转运体 ^99mTcO4^-显像 ^131I治疗 卵巢癌 Human sodium/iodide symporter ^99mTcO4^- imaging ^131I treatment Ovarian cancer
分类号 R686 [医药卫生—骨科学]
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参考文献17

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二级参考文献29

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中华内分泌代谢杂志
2009年 第1期

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