针灸对帕金森病大鼠模型脑内单胺类递质含量的影响

Effects of Acupuncture-Moxibustion on the Contents of Monoamine Transmitters in the Striatum of Rats in Parkinson's Disease

本研究初步观察了大鼠帕金森病模型纹状体内三种单胺类递质多巴胺（DA）、去甲肾上腺素（NA）、5-羟色胺（5－HT）针灸治疗前后的变化情况，在此基础上，为了摸索针灸的临床治疗规律，本组资料选择了不同选穴和不同针灸方法进行分组，观察这些针灸刺激因素对单胺类递质的不同影响。结果发现，针灸后大鼠纹状体内DA、NA、5－HT明显上升，此外，从选穴的角度看，头部选穴明显优于四肢，头部选穴各组差别虽无统计学意义，但组间差别似乎反应，针刺方法作用较平均，艾灸和电刺激方法对儿茶酚胺类递质作用更明显。

In this research, the changes of three monoaminotransmitters, ie. dopamine (DA), noradreanine (NA) and serotoniu(5-HT), in striatum corpus of Parkinson's disease rat model induced by 6-hydrox-ydopamine (6-OHDA) before and after acupuncture and moxibustion therapy were compared. Also the different effects of various acupuncture stimulation factors were observed. The results showed that the levels of three transmitters were significantly elevated after the treatment of Acu. & Mox. And among the treatment groups, the effects of Baihui and Dazhui points were better than Siguan group selected from limb points. The authors consider that Acu. or Mox. is a good way to raise monoaminotransmitters in rat brain, therefore it conduces to the recovery of Parkinson's disease.