200例脑囊虫病疗效及不良反应分析

Analysis of efficacy and untoward reaction on 200 cases of brain cysticercosis

目的评价阿苯达唑、吡喹酮治疗脑囊虫病的疗效及不良反应。方法将2002—2007年收治的脑囊虫病病例资料，随机抽取200例，分单纯使用阿苯达唑治疗组58例和吡喹酮、阿苯达唑联合治疗组142例两组，进行上述目的分析。结果治疗后两组临床有效率差异无统计学意义（P＞0．05）；颅内高压症、癫痫发作、精神症状的不良反应发生率阿苯达唑组少于联合治疗组，差异有统计学意义（P＜0．05）；过敏反应两组差异无统计学意义（P＞0．05）。结论阿苯达唑、吡喹酮治疗脑囊虫病疗效肯定，但吡喹酮和阿苯达唑联合用药的不良反应较阿苯达唑单独用药严重。

Objective To assess the efficacy and untoward reaction of Albendazole, Praziquantel in treatment of brain cysticercosis. Method 200 brain cysticercosis patients＇ data were selected randomly, which were treated from 2002 to 2007, and divided into two groups. 58 cases in group A were treated with Albendazole alone, 142 cases in group B were treated with both Praziquantel and Albendazole, and then the efficacy and untoward reaction between the two groups were compared. Results The efficacy of two groups was almost the same（ P 〉 0.05）. The incidence of untoward reaction of group A was less than that in group B, such as intracranial hypertension, falling sickness, mental symptom（P〈0.05）, but the incidence of anaphylaxis of the two groups was almost the same （P 〉 0.05）. Conclusions Albendazole mad Praziquantel have certain clinical efficacy in treatment of brain cysticercosis, but untoward reaction of drug condzination is more serious.