TCRβ链CDR3概况与感染性疾病的研究

Study for complementarity determining region 3 of T cell receptor beta chain in infectious diseases ＂

外周血大部分T细胞膜表面抗原受体分子（TCR）由α/β多肽链构成，α/βBTCR特异性识别抗原多肽与MHC分子复合物。分析克隆性增生TCRBVCDR3的基因谱型特征，可以了解机体T细胞增殖与功能状况，从而有助于T细胞相关疾病的诊断和治疗，通过直接移植特异性T细胞来治疗相关疾病，也能发展以特异性TCR基因为基础的转基因技术来治疗相应疾病。此文主要就TCRβ链特点及其在感染性疾病的诊断与治疗上的应用作了阐述。

Most of the peripheral blood T lymphocyte antigen receptor （TCR） molecules on the surface membrane organized with α and β peptide chain, and α/β TCR identifies specific antigen peptide with MHC molecules complex. Analysis of clonal proliferation of TCR BV CDR3 gene patterns characteristic of the body can understand the statue of T cell proliferation and function situation, contributing to diagnosis and treatment for the T cell-related diseases. The specific T cell can be transplanted directly for treatment of related diseases, and the specific TCR gene-based transgenic technology can be used to treat corresponding diseases as well. In this article, the characteristics of TCR β chain and its application in diagnosis and treatment for infectious disease are discussed.