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羟乙膦酸二钠治疗绝经后骨质疏松症93例

CLINICAL TRIAL OF DOMESTIC DISODIUM ETIDRONATE IN TREATMENT OF 93 POSTMENOPAUSAL OSTEOPOROSIS
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摘要 目的:考察国产羟乙膦酸二钠(康骨片)治疗绝经后骨质疏松症的疗效和安全性。方法:将93例绝经后骨质疏松患者随机双盲法分治疗组,安慰剂对照组。治疗组服康骨片,1片/次,bid,连服2周,继之服乳酸钙8片/d,连服11周,再重复1疗程。安慰剂组服法同治疗组。结果:经2个疗程6个月的治疗,治疗组腰椎2~4和Wards三角区等部位治疗后骨密度增加显著,对照组4个骨密度检测指标均无显著变化。两组间比较,腰椎2~4骨密度指标有显著性差异。还可缓解因骨质疏松引起的腰背痛等症状,增加关节活动度。治疗期间未见明显的副作用,治疗组晨尿Hop/Cr下降显著,表明能抑制骨吸收。 OBJECTIVE:To observe the efficacy and safety of domestic disodium etidronate in treatment of postmenopausal osteoporosis.METHODS:93 patients with postmenopausal osteoporosis were randomly and doubleblindly divided to recieve domestic disodium etidronate tablet(EHDP)or placebo.The EHDP group is given 1 tablet/time,bid for 2 weeks,then calcium lactate 8 tablets/day for 11 weeks.The placebo group is the same.RESULTS:After 6 months (2 periods)treatment the bone mass density (BMD)was increased significantly in the active group and no statisticalincrease in the control group.CONCLUSION:The results indicated that EHDP is an effective and safe drug for treatment of postmenopausal osteoporosis.
出处 《中国新药杂志》 CAS CSCD 1998年第3期199-201,共3页 Chinese Journal of New Drugs
关键词 羟乙膦酸二钠 康骨片 绝经后 骨质疏松症 骨密度 Clinical trial Disodium etidronate EHPD Postmenopausal osteoporosis Bone mass density
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