眼用药膜配方的改进

IMPROVEMENT IN FORMULATION OF OPHTHALMIC FILM

目的：为了延长药物溶出时间和改进膜的柔软性而改进眼用载药膜的配方。方法：以聚乙烯醇（ＰＶＡ）和白芨胶为药膜基质，制备氢溴酸后马托品眼用药膜，并进行体外溶出度和动物试验。结果：在ＰＶＡ膜质中加入白芨胶可以改进ＰＶＡ膜的药物缓释性能及膜的柔软性。

OBJECTIVE:In order to extend the drug dissolution rate in ophthalmic film and improve its flexibility,the improvement in formulation of ophthalmic film was studied.METHODS:Polyvinyl alcohol and gum bletilla were adopted as the film base and homatropine hydrobromide ophthalmic film was prepared.Then its dissolution rate in vivo was determined and be tested on animals.RESULTS:The dissolution rate and flexibility of the ophthalmic film could be improved by adding gum bletilla into PVA.CONCLUSION:The formulation for the film base selected by the author was proved reasonable.