索他洛尔(sotalol)对急性心肌梗死心率变异功率谱的影响及预后观察

Effects of sotalol on heart rate variability in patients with acute myocardial infarction.

２６例急性心肌梗死患者，应用索他洛尔治疗，并测定心率变异功率谱，发现用药后５天、１０天之功率谱较用药前有明显增加（Ｐ＜０．０５），与对照组相比亦有显著差异（Ｐ＜０．０５），应用索他洛尔组心肌梗死后心律失常发生率较对照组明显降低。

The effects of sotalol on heart rate variability(HRV) were studied in 26 patients with acute myocardial in farction(AMI).It was found that HRV was prolonged in patients with AMI with sotalol after 5 days and 10 days.The differences of HRV between treatment group with sotalol and control group were significant (P<005).The occurrence rate of cardiac arrhymias was lower in treatment group with sotalol than control group。