壳糖胺对受照鼠30日存活率的影响

Effect of Chitosan on 30Day Survival Rate of Irractiated Mice

将１２０只小鼠分成３个实验组：给药照射组（ＣＴＳ＋Ｉ）、照射给药组（Ｉ＋ＣＴＳ）、给药照射给药组（ＣＴＳ＋Ｉ＋ＣＴＳ）。每组又分为不同剂量组（单纯照射对照组，１２５、２５０、５００ｍｇ／ｋｇ）组。对各组小鼠进行６０ＧＹχ射线照射，观察壳糖胺（Ｃｈｉｔｏｓａ，ＣＴＳ）对受照小鼠在不同时间段的平均存活天数、存活率及保护指数的影响。结果表明：由于使用了ＣＴＳ大大提高了受照小鼠的存活率，平均存活时间与保护指数。说明在照射前预防给药能更好的起到吸附Ｘ射线和消除自由基的作用，提高小鼠的存活率。

One hundred and twenty mice were divided into three experimental groups,drugged and irradiated group(CTS+I),irradiated and drugged group(I+CTS),drugged,irradiated and drugged group(CTS+I+CTS).The mice in every group were divided into four groups,control group of only irradiation,the group of 125,250and 500mg/kg.The effect of Chitosan(CTS)on the survival rate,average survival time and protection index of every period was observed aftcr each group mice were exposed to 60GY Xray.The results showed that the CTS made the survival rate,the average survival time and the protection index increased significantly.There were significant difference compared with control group.(P<005,P<001).The most effective one was the (CTS+I)group in all groups.The survival rate was 100%,80%and 70% in 10d,20d and 30d.And it was 70%,10% and 0% in the control group.The result suggested that the CTS can get a better cffect of absorbing Xray and caneel freeradical,drugged before irraidiation.So the suvival rate of mice were increased.