糖肽和环脂肽抗生素的进展与临床评价

Progress and Clinical Evaluation of Glycopeptides and Cyclic Lipopeptide Antibiotics

目的:半合成的糖肽类抗生素进展迅速,作用机制与万古霉素相同,药动学性质独特,在各种耐药菌株十分猖獗的历史瞬间,尤显重要,本文就其抗菌活性、药动学特征、临床评价作一概述。方法:通过国内、外近期文献进行综述。结果及结论:作为抗菌药物中的一枝奇葩,糖肽和环脂肽类抗生素为对抗耐药细菌感染的治疗提供了全新的效果,在呼吸系统感染、导管相关性血源感染、皮肤及软组织感染上应用日趋广泛,标志着一个新的里程的开始。

OBJECTIVE： Rapid progress in semi - synthetic peptide antibiotics has been made in recent years. Its mechanism of action similar to vancomycin and distinctive pharmacokinetics make it even more important in light of the present widespread drug resistant strains. The paper aimed to summarize the antibacterial activity, pharmacokinetie characteristics and clinical evaluation on the glycopeptides and eyclopeptides antibiotic. METHODS： The pertinent literature both at home and abroad was reviewed. RESULTS ＆ CONCLUSION： As an exotic flower among antibacterial drugs, new glycopeptides and cyclopeptides antibiotics provide of brand - new efficacy against resistant - bacterial infection, and their widespread use in treating infection of respiratory system, catheter- related blood system infection and infection of skin and soft tissue system indicates a new start of in clinical treatment.