摘要
为探讨防感灵(流感疫苗)的安全性和免疫效果,于1996年对60岁以上的老人、18~40岁成人、3~6岁儿童各50人进行全程接种。接种后进行连续三天全身和局部反应观察并用血凝抑制试验作免疫前后抗体测定。结果接种后反应轻微,未见异常反应,仅1人出现发热,5人出现局部疼痛,副反应率为4.0%,出现的副反应在接种后24小时均自动消失。接种后流感HI抗体阳转率:H3N2为87.7%;H1N1为88.4%,B型为81.6%。免疫后三周HI抗体平均滴度GMT分别为:H3N21∶71.09,H1N11∶102.61,B型1∶30.57。本研究结果表明防感灵具有安全性高、免疫效果良好的特点,值得推广使用。
In order to study the safety and efficacy of inactivated influenza vaccine (Vaxigrip),50 elders over 60 of age ,50 adults 18 to 40 of age and 50 children 3 to 6 of age were injected completed doses in 1996.The general and local side post vaccination reactions were observed for three days after immunization.The infuenza HI antibody was determined by hemagglutination inhibition test before and after immunization.The results showed that,the post vaccination reactions were slight,the rate was 4.0%(6/150).There was on severe reaction in recipients.The seroconversion rates of HI antibody were 87.7%(H3N2),88.4%(H1N1) and 81.6%(B) respectively.The geometric mean titres (GMT) three weeks after injection were 1∶71.09 (H3N2),1∶102.61(H1N1) and 1∶30.57 (B).The results suggested that this vaccine was safety and effective for human use .
出处
《疾病监测》
CAS
1998年第4期131-133,共3页
Disease Surveillance
关键词
流感疫苗
接种反应
抗体阳转率
抗体平均滴度
Inactivated Influenza Vaccine (VAXIGRIP) Safety and Efficacy of Vaccine