肾上腺髓质素对慢性肾衰竭及血液透析患者血压的影响
摘要
肾上腺髓质素(adrenomedullin,ADM)是日本学者Kitamure等于1993年从人肾上腺嗜铬细胞瘤中分离纯化出一种由52个氨基酸组成的多肽。而应用免疫组织化学定位和杂交表明,肾脏是ADM分布较高的器官之一,其含量依次为嗜铬细胞瘤肾上腺〉肺〉肾脏〉脑皮质、小肠、心脏。ADM在肾脏功能调节中发挥重要作用,但随着肾衰竭进展至尿毒症血液透析时而成为毒素,属于中分子物质,血浆及组织ADM水平明显升高,而维持性低血压血液透析患者血浆及组织ADM水平更高,对血压影响及其机制。本文就该方面的内容予以综述。
出处
《中国血液净化》
2009年第2期92-95,共4页
Chinese Journal of Blood Purification
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