期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Mimecan基因的研究进展 被引量：3

Current concept review:mimecan gene
下载PDF
导出
摘要 Mimecan属亮氨酸富集蛋白家族(small leucine-rich proteoglycan,SLRP),有3种亚型:osteoglycin,keratan sulfate glycoprotein和mimecan,在人类的多种组织中表达,具有重要的生理病理功能。Mimecan在胶原纤维的生成、细胞生长、分化和迁移过程中发挥着重要作用,与纤维化疾病和骨疾病关系密切。此外,mimecan在结直肠肿瘤、垂体瘤和肝癌等恶性肿瘤中的表达与正常组织不同,提示其可能与这些肿瘤的发生有关。 Mimecan belongs to a family of small leucine-rich proteoglycans （SLRPs） inclnding 3 isoforms （osteoglycin, keratan sulfate glycoprotein, and mimecan）, which is expressed in a variety of human tissues and has an important function of physiology and pathology. Mimecan plays an important role in the process of collagen fibrillogenesis, cellular growth , differentiation, and migration. Also is closely related to the diseases of fibrosis and bone. Moreover, the expression of mimecan in colorectal tumors, pituitary tumor and liver cancer is different from the corresponding normal tissue, suggesting that it may be correlated with the occurrence of these tumors.
作者 年娣 王萍
机构地区 蚌埠医学院第一附属医院病理科 安徽省感染与免疫重点实验室
出处 《国际病理科学与临床杂志》 CAS 2009年第1期41-44,共4页 Journal of International Pathology and Clinical Medicine
关键词 mimecan 亮氨酸富集蛋白 肿瘤 mimecan small leucine-rich proteoglycan tumor
分类号 R363 [医药卫生—病理学] R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献3

二级参考文献26

  • 1Yu-Kun ZHANG,Gui-Fang SHEN,Bing-Gen RU.Survival of Human Metallothionein-2 Transplastomic Chlamydomonas reinhardtii to Ultraviolet B Exposure[J].Acta Biochimica et Biophysica Sinica,2006,38(3):187-193. 被引量：4
  • 2李圣青,赵峰,戚好文,张晓君,赵馨,潘刚,吴哲,王宇,阙海萍,刘少君.肺组织灌注前后双向电泳的比较[J].西安交通大学学报（医学版）,2006,27(2):203-206. 被引量：12
  • 3Hui TIAN,Lin LI,Xian-Xi LIU,Yan ZHANG.Antitumor Effect of Antisense Ornithine Decarboxylase Adenovirus on Human Lung Cancer Cells[J].Acta Biochimica et Biophysica Sinica,2006,38(6):410-416. 被引量：15
  • 4Funderburgh J L, Corpuz L M, Roth M R, Funderburgh M L, Tasheva E S, Conrad G W. Mimecan, the 25-kda corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin. J Biol Chem, 1997, 272: 28089 ～ 28095
  • 5Ujita M, Shinomura T, Kimata K. Molecular cloning of the mouse osteoglycin-encoding gene. Gene, 1995, 158(2) :237 ～ 240
  • 6Shanahan C M, Cary N R, Osbourn J K, Weissberg P L. Identification of osteoglycin as a component of the vascular matrix. Differential expression by vascular smooth muscle cells during neointima formation and in atherosclerotic plaques. Arterioscler Thromb Vasc Biol, 1997, 17(11) :2437 ～ 2447
  • 7Hu R M, Han Z G, Song H D, Peng Y D, Huang Q H, Ren S X, Gu Y J, Huang C H, Li Y B, Jiang C L, Fu G, Zhang Q H, Gu B W,Dai M, Mac Y F, Gao G F, Rong R, Ye M, Zhou J, Xu S H, Gu J,Shi J X, Jin W R, Zhang C K, Wu T M, Huang G Y, Chen Z, Chen M D, Chen J L. Gene expression profiling in human tissues of hypothalamus-pituitary-adrenal axis by expressed sequence tags (ESTs)and full-length cDNA cloning. Proc Natl Acad Sci USA, 2000, 97(17) :9543 ～ 9548
  • 8Sambrook J, Fristch E F, Maniatis T. Molecular Cloning. A Laboratory Manual, 2nd ed. New York: Cold Spring Harbor Laboratory Press.1989
  • 9Dasch J R, Pace D R, Avis P D, Bentz H, Chu S. Characterization of monoclonal antibodies recognizing bovine bone osteoglycin. Connect Tissue Res, 1993,30(1): 11 ～ 21
  • 10Tasheva E S, Koester A, Paulsen A Q, Garrett A S, Boyle D L,Davidson H J, Song M, Fox N, Conrad G W. Mimecan/osteoglycindeficient mice have collagen fibril abnormalities. Mol Vis, 2002, 8:407～ 415

共引文献10

同被引文献86

  • 1Klareskog L, Catrina A, Paget S. Rheumatoid arthritis[J]. Lancet,2009, 373(9664): 659-72.
  • 2Chugh S, Suen C, Gramolini A. Proteomics and mass spectrometry:what have we learned about the heart[J]? Curr Cardiol Rev, 2010, 6(2): 124-33.
  • 3Bentz H, Nathan RM, Rosen DM, et al. Purification andcharacterization of a unique osteoinductive factor from bovine bone[J]. J Biol Chem, 1989, 264(34): 20805-10.
  • 4Kukita A, Bonewald L, Rosen D, et al. Osteoinductive factorinhibits formation of human osteoclast-like cells[J]. Proc Natl AcadSci USA, 1990, 87(8): 3023-6.
  • 5Yang X, Wang J, Liu C, et al. Cleavage of p53-vimentin complexenhances tumor necrosis factor-related apoptosis-inducingligand-mediated apoptosis of rheumatoid arthritis synovialfibroblasts[J]. Am J Pathol, 2005, 167(3): 705-19.
  • 6Bang H, Egerer K, Gauliard A. Mutation and citrullination modifiesvimentin to a novel auto antigen for rheumatoid arthritis[J].Arthritis Rheum, 2007, 56(8): 2503-11.
  • 7Mathsson L, Mullazehi M, Wick MC, et al. Antibodies againstcitrullinated vimentin in rheumatoid arthritis: higher sensitivity andextended prognostic value concerning future radiographicprogression as compared with antibodies against cyclic citrullinatedpeptides[J]. Arthritis Rheum, 2008, 58(1): 36-45.
  • 8Chen S, Mienahowski MJ, Birk DE. Regulation of corneal stroma extracellular matrix assembly [ J ]. Exp Eye Res, 2015,133 : 69- 80. doi : 10. 1016/j. exer. 2014.08. 001.
  • 9Chaerkady R, Shao H, Scott SG, et al. The keratoconus corneal proteome:loss of epithelial integrity and stromal degeneration [ J ]. J Proteomics,2013,87 : 122-131. doi: 10. lO16/j, jprot. 2013.05. 023.
  • 10Mi S,Connon CJ. The formation of a tissue-engineered cornea using plastically compressed collagen scaffolds and limbal stem cells [ J ]. Methods Mol Biol,2013,1014 : 143 - 155. doi: 10. 1007/978-1 ~2703-432-6_9.

引证文献3

二级引证文献7

国际病理科学与临床杂志
2009年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部