脂联素——一种新的抗炎因子

Adiponectin:an new anti-inflammatory factor

动脉粥样硬化是一种以慢性轻度炎症为特征的疾病。脂联素(ad iponectin,Adp)作为脂肪组织分泌的一种脂肪细胞因子具有改善胰岛素敏感性、保护血管内皮功能、抗动脉粥样硬化及抗炎作用。多项临床研究表明血浆Adp水平与多种炎症标志物呈负相关。在多种细胞中Adp能减轻炎症刺激物引起的炎症反应。Adp的抗炎特性可能是其对心血管和代谢性疾病如动脉粥样硬化及胰岛素抵抗起有利作用的主要原因。

Atherosclerosis is characterized by low-grade systemic inflammation. Adiponectin （Adp） is a novel adipose tissue-derived cytokine that has been shown to improve insulin sensitivity and protect endothelial cell function, and to exert antiatherosclerotic and anti-inflammatory effects. Several clinical studies demonstrated the inverse relationship between plasma adiponectin levels and several inflammatory markers. Adp attenuates inflammatory responses to multiple stimuli by modulating signaling pathways in a variety of cell types. The anti-inflammatory properties of adiponectin may be a major component of its beneficial effects on cardiovascular and metabolic disorders including atheroselerosis and insulin resistance.