升白素的生殖毒性研究

A STUDY ON REPRODUTIVE TOXICITY OF SHENG BAISU

目的：观察升白素（Ｄ－高炔雌醇－３乙酸酯）的生殖毒性。方法：用电子天平、游标计量尺和病理组织学方法观察小鼠和大鼠的生殖毒性。结果：一般生殖毒性结果表明０．２５～０．５ｍｇ／ｋｇ使雄性小鼠体重增长缓慢（Ｐ＜０．０１），但受孕率、胎鼠数和胎鼠体重等均无改变。致畸试验结果指出升白素０．５～１．０μｇ／ｋｇ对小鼠体重、生育能力和胎鼠生长发育均无影响，也无外观、骨骼和内脏畸形出现，围产期毒性试验结果表明升白素２．０μｇ／ｋｇ使Ｆ１代仔鼠体重增长明显减慢（Ｐ＜０．０５），但对Ｆ１代仔鼠的一般体征、中枢神经系统发育及生殖机能均无影响。结论：升白素在本试验条件下未产生一般生殖毒性、致畸性和围产期毒性。

Objective:To observe the reproductive toxicity of Sheng Baisu(Dhyperethiny estradiol3 acetic ester) in the rats and miceMethods:Use electronic balance, movable measurement ruler and method of histopathology to observe reproductive toxicity of the rats and miceResults:The results of general reproductive toxicity of Sheng Baisu indicated that 025-05mg/kg doses could produce decrease in body weight of male mouse (P<001) but did not influence coitus rate, conception rate, fetus mouse number and fetus body weight The results of teratogenicity test in the rat indicated when Sheng Baisu was administrated S C at 05μg/kg and 10μg/kg on day 6-15 of gestation, there was not embryo toxicity, it did not influence growth and development of fetus, and did not cause deformities of the fetus appearances, bone and internal organs, either The results of prenatal toxicity test indicated that only 20μg/kg of Sheng Baisu caused decrease in body weight of F1 generation mice significantly, but it did not influence development of central nervous system and reproductive function of F1 generation miceConclusions:Sheng Baisu did not produce general reproductive toxicity fetus toxicity, teragenecity and prenatal toxicity