瘤内血管密度与声门上型喉癌相关性研究

Study on the relation between intratumor microvessel density and supraglottic type laryngeal carcinoma

为探讨肿瘤血管生成与喉鳞状细胞癌转移及预后的关系,我们采用免疫组化 SP 法用抗 FⅧ因子多克隆抗体对36例声门上型喉癌(T_1～T_2)内的血管进行标记及分析,结果显示:淋巴结转移组血管密度(30.52±5.31)明显高于无淋巴结转移组(16.28±6.15)(P<0.01)。随访发现,血管密度高表达组和低表达组,颈淋巴结术后复发率分别为66.67%和9.52%,两者比较有显著的统计学意义(P<0.01)。研究结果表明,肿瘤内血管密度与喉鳞癌转移密切相关,它可作为判定喉癌转移的预后指标。

Expression of intratumor microvessel density (MD) was investigated by immuno- histochemical SP method using a polyclonal antibody to F Ⅷ on 36 patients with supraglottic squamous cell carcinoma (stage T_(1～2).Thirty-six patients were divided into two groups:cervical-lymph-node metastasis (group A,11 cases),and no cervical- lymph-node metastasis (gruop B,25 cases).Our result showed that the expression of MD was higher (30.525±5.31) in group A than that in group B (16.28±6.15) (P< 0.01).The recurrence rate was 66.67% in higher expression group (15 cases,MD≥ 20.34),9.52% in lower expression group (21 cases,MD<20.34)(P<0.01).It is indicated that the expression of intratumor MD is related to the metastasis of laryngeal carcinoma.