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结核分枝杆菌散在重复单元分型技术在监狱结核病暴发中的应用

Value of Mycobacterial Interspersed Repetitive Unit on Tuberculosis Outbreak in Prison
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摘要 目的探讨结核分枝杆菌散在重复单元在监狱结核病暴发中的应用价值。方法应用结核分枝杆菌散在重复单位(MIRU)基因分型技术,对监狱结核病患者结核分枝杆菌分离株DNA进行基因型检测分析。结果7例监狱结核病患者结核分枝杆菌分离株中,6例结核分枝杆菌分离株MIRU基因型为233325153533,另一分离株MIRU基因型为242325152322;6例监狱结核病患者为同一传染源直接传播的结果,而另1例患者和其他6例患者非同一传染源传播。结论MIRU基因分型技术中结核病暴发时追踪传染源是可行的。 OBJECTIVE To explore the value of molecular epidemic technology on tuberculosis outbreak in prison. METHODS Using mycobacterial interspersed repetitive unit (MIRU) genotyping to discriminate and recognize 7 strains on tuberculosis cases. RESULTS Among 7 Mycobacterium tuberculosis isolates, 6 strains' MIRU genotyping was 23332515-3533, another one was 242325152322. Six M. tuberculosis cases were infected by the same MIRU genotyping tuberculosis strains, but another one was not. CONCLUSIONS MIRU genotyping to discriminate and track source of infection is possible.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2009年第5期503-504,共2页 Chinese Journal of Nosocomiology
关键词 结核病 暴发 结核分枝杆菌散在重复单元 监狱 Tuberculosis Outbreak Mycobacterial interspersed repetitive unit Prison
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