312株金黄色葡萄球菌耐药特性的研究

Drug Resistance of 312 Staphylococcus aureus strains

目的研究金黄色葡萄球菌(SAU)临床分离株的耐药特性。方法用K-B法测定20种常用抗菌药物的敏感性;头孢西丁纸片法测定MRSA;D试验测定克林霉素的诱导耐药情况。结果SAU的耐药性普遍较高,除万古霉素、米诺环素、替考拉宁、呋喃妥因和利福平外,其余抗菌药物耐药率均≥42.6%;312株SAU检出MRSA209株,检出率67.0%;克林霉素结构性耐药占29.5%,诱导耐药检出率51.4%。结论SAU的总耐药率日趋严重,MRSA和D试验高阳性率,对临床抗菌药物的选择构成极大的困难,必须引起临床的高度重视。

OBJECTIVE To study the antimicrobial agents resistance of Staphylococcus aureus isolated from clinic. METHODS To test the sensitivity of 20 common antimicrobial agents by K-B. MRSA was detected by cefoxitin disk ; and the inducible resistance of clindamycin was detected by D-test. RESULTS The drug resistance rate of this term of S. aureus was high. Except vancomycin,minocycline, teicoplanin, nitrofurantoin and rifampin, the drug resistance rate was higher than 42.6%. From 312 strains of S. aureus 209 strains of MRSA were detected, the rate was 67. 0%. The structural antimicrobial resistance rate of clindamycin was 29.5%, the detection rate of inducible resistance was 51.4 %. CONCLUSIONS The antimicrobial resistance of S. aureus is increasingly severe. The high positive results of MRSA and D-test make great trouble to therapy, and should have taken more attention of clinic.