医院感染假丝酵母菌属的临床分布及抗真菌药物敏感分析

Candida Infection:Its Clinical Distribution and Antifungal Sensitivity

目的研究医院内假丝酵母菌属感染的状况、临床分布及对抗真菌药物的敏感情况。方法采用回顾性调查方法，对2002年1月-2006年12月住院患者年龄、标本、菌种分布、药敏试验进行分析，采用WHCINET5进行统计研究。结果5年检出假丝酵母菌属分别为23、58、100、170、150株，共501株；患者年龄在2个月～89岁，〉60岁占68．1％；以痰液标本为主，占66．1％，其次为尿液、血液、咽拭子、肺泡灌洗液、脓液、引流液、阴道分泌物、静脉导管、腹水、前列腺液、伤口、胸水，分别占17．8％、4．8％、2．4％、2．2％、1．6％、1．4％、1．0％、0．8％、0．6％、0．6％、0．4％、0．4％；菌种分布以白色假丝酵母菌、热带假丝酵母菌、光滑假丝酵母菌为主，分别占56．1％、28．5%、8．8％；白色假丝酵母菌对4种抗真菌药物的敏感性均有较高的活性。结论医院内假丝酵母菌属感染逐年增加，多发生于〉60岁老年患者，感染部位以下呼吸道多见，氟康唑对白色假丝酵母菌有较好的抗菌活性。

OBJECTIVE To study the Candida infection, its clinical distribution and susceptibility of antifungal agents in hospital from Jan 2002 to Dec 2006. METHODS The data of the patients＇ age, samples, species distribution and antifungal sensitivity tests were retrospectively analyzed with WHONET 5. RESULTS A total of 501 cases with Candida were detected in these five years, from them 89 were older than 60, accounted for 68.1V0. sputum was predominant samples, accounted for 66.1%. The main strain species were Candida albicans and C. tropicalis, C. glabrata,which were accounted for 56. 1% ,28.5% and 8.8%, respectively. C. albicans isolates were susceptible to four antifungal agents. CONCLUSIONS The Candida infection in hospital is increasing year by year, most of them occurred in old people. The most common infection site is lower respiratory tract. Fluconazole （FLU） is good susceptible to Candida.