76例新生儿败血症病原菌及药敏结果分析

Distribution and Antibiotic Susceptibility of Pathogens Isolated in 76 Cases of Neonatal Septicemia

目的了解近年新生儿败血症病原菌构成及耐药状况,以指导临床治疗。方法对2005年1月-2008年1月住院的经血培养证实阳性的76例新生儿败血症的临床资料进行回顾性分析。结果凝固酶阴性葡萄球菌(CNS)为主要病原菌,其中表皮葡萄球菌占47.36%,其次溶血性葡萄球菌占10.53%,金黄色葡萄球菌占9.21%,大肠埃希菌占7.88%;病原菌对青霉素、氨苄西林、红霉素耐药性高,万古霉素、亚胺培南、环丙沙星、阿米卡星是目前最敏感抗菌药物。结论引起新生儿败血症的病原菌以革兰阳性球菌为主,CNS为主要病原菌,临床应根据血培养药敏结果选用敏感抗菌药物,以减少病原菌耐药性的产生,提高治疗效果。

OBJECTIVE To investigate pathogens in neonatal septicemia and the antimicrobial resistance of these bacteria in recent years to guide the clinical treatment. METHODS The data of 76 neonatal septicemia confirmed by hemoculture from Jan 2005 to Jan 2008 in our hospital were analyzed retrospectively. RESULTS Coagulasenegative Staphylococcus （CNS） were the main pathogens, among which their were 47.36% of S. epidermidis, 10.53% of S. haemolyticus, 9. 21% of S. aureus, and the others of 7. 88% Escherichia coll. Bacteria were highly resistant to penicillin, ampicillin and erythromycin. Vancomycin, imipenem, ciprofloxacin and amikacin were the most sensitive drugs. CONCLUSIONS Gram positive cocci are main pathogens in neonatal septicemia, in which the CNS are the most common ones. To choose sensitive antibiotics bases on the drug sensitivity tests may decrease the occurrence of drug resistance to bacteria and increase the clinical curative effects.