氨苯砜-联磺甲氧苄啶与双氢青蒿素治疗大鼠实验性卡氏肺孢子虫肺炎的对比试验

Efficacy of dapsone-synergic sulphonamides compound and dihydroarteminsinin on rat Pneumocystis carinii pneumonia

为检测氨苯砜-联磺甲氧苄啶与双氢青蒿素对大鼠PCP的确切疗效,用免疫抑制剂处理建立大鼠PCP模型,随机分为试验Ⅰ组、试验Ⅱ组和对照组。用临床观察、肺PC包囊荷量测定、肺泡PC感染率测定3项指标考核疗效。结果证实建立的大鼠PCP模型,均为重度感染;经统计学处理,试验Ⅰ组、试验Ⅱ组的3项指标明显低于对照组(P<0.05);试验Ⅰ组与试验Ⅱ组则无显著性差异(P>0.05)。表明氨苯砜-联磺甲氧苄啶与双氢青蒿素对大鼠PCP均有较好疗效,前者优于后者。

The aim of this research was to estimate the effect of dapsone-synergic sulphonamides compound and dihydroarteminsinin on rat Pneumocystis carinii pneumonia （PCP）, and the PCP models were established in 39 SD rats by injection of cortisone acetate for 8 weeks. The rats were randomly divided into 3 groups. The group Ⅰ was given 25 mg dapsone and 0. 125 g synergic sulphonamides compound/ rat · d for 10 d, and group Ⅱ was given 20 mg dihydroarteminsinin/rat · d for 10 d, but group Ⅲ was not given any drugs. The efficiency of dapsone-synergic sulphonamides compound and dihydroarteminsinin on PCP were estimated by change of clinical signs, the burden of PC and the infection rate of PC in pulmonary alveolus. Eleven died rats were subject to etiologic and pathologic examination. All of rate were seriously infected by PC and the statistic analysis showed that three targets of group Ⅰ and group Ⅱ were evidently lower than controls （P〈0.05） and there was no significant difference between the group Ⅰ and the group Ⅱ （P〈0.05）. The results showed that dapsone-synergic sulphonamides compound and dihydroarteminsinin were high curative effect.