老年癌症患者手术前后血小板活化状态检测的临床意义

Flow Cytometric Detection of Activated Platelet Before and After Surgical Operation in Aged Patients with Carcinomas

应用流式细胞免疫学技术对58例肿瘤患者手术前后外周血小板活化分子P-选择素和凝血酶敏感蛋白进行了对比研究。结果术后外周血P-选择素及凝血酶敏感蛋白较术均明显增加，有统计学意义。其中P-选择素增加更为显著（P<0．01）。男性患者术前后血小板活化状态较女性患者更为明显。本研究提示手术对癌症患者血小板有明显的活化作用，在男性更为显著，应重视手术后的防凝措施，防止血栓病的发生。

To investigate the difference of activated platelet levels between before and afterSurgical operation in aged patients with carcinomas. In 58 aged cancer patients, the authors studiedthe positive platelet percents of P--selectin(CD62p) and thrombospodin (P10) in peripheral blood respectively before and after surgery by flow cytometric immunology. The levels of CD62P and P10positive platelet percents in peripheral blood after surgery were statistically higher than those before(P< 0.01 ). The CD62P and P10 positive platelet percent increased much more in the male pattensthan in the females. Surgical operation may stimulate the platelet activity in aged patients with carcinomas. It was more significant in males. Thus, measures of anticoagulation after surgery should betaken to avoid possible thrombosis.