新型铜药复合IUD的体外药物释放研究

Study on drug releasing of new type of LNG - Cu-IUD.

目的:检测铜药复合型IUD中LNG在体外长期释放的稳定性。方法:在体外释放介质中连续测定药物释放1年。结果:测得平均日释放量为6.23±0.22μg。在稳态释放阶段药物释放速率是一个常数。铜材溶蚀对药物释放无影响。结论:研究证明IUD中LNG体外释放率稳定,符合设计要求。

a year was 6. 23 ± 0.22μg/day. During steady releasing state, releasing rate of LNG was a constant. Corrosion of copper from devices did not interfere drug releasing. 21 of volunteers were involved in this study for one year. By the method of remnant LNG analysis, the average steady state releasing rate per day was 6. 98 ± 1. 94μg/day. The characteristics of drug releasing were similar in vivo and in vitro. It is concluded that the releasing rate of LNG in vivo and in vitro is stable and accords with demands of experimental design.The purpose of this study is to determine stability of LNG releasing of LNG - Cu - IUD in vivo and in vitro. The average releasing rate of LNG at medium for