高压氧与一氧化氮促进高原缺氧后脑功能康复的疗效观察

EFFECTS OF HBO AND NO ON BRAIN FUNCTION UNDER HIGH ALTITUDE CONDITION IN YOUTH RETURNED TO SEA LEVEL FROM HIGH ALTITUDE

目的：为促进久居高海拔地区（5000m以上）返回平原后人脑功能的尽早康复，保证高寒地区人群身心健康，我们选择了驻守5380m、5200m、5001m一年返回平原（1400m）的24名青年，分组进行高压氧（HBO）和一氧化氮（NO）的脑功能康复治疗;方法：采用韦氏智力量表（WAIS-RC）与记忆量表（WMS）和DX-A型电脑多项心理测试仪对HBO及NO治疗前后脑功能的变化进行了测验;结果：HBO治疗后的智力与记忆功能明显优于治疗前，多项心理测验TEST1（视听简单反应时）、TEST2（交叉动作反应时）、TEST3（动作频率）、TEST4（视觉反应和瞬态记忆）、TEST5（视觉品质注意分配）中的分测验Error（错误）明显较治疗前减少，反应速度显著增快（P＜0.01或P＜0.05）;NO治疗后的智力水平明显优于治疗前（P＜0.05），记忆及多项心理部分测验较治疗前显著提高（P＜0.01或P＜0.05）。HBO与NO治疗后比较，HBO对促进脑功能康复的作用优于NO治疗后（P＜0.01或P＜0.05）;结论：HBO与NO对慢性乏氧性脑功能损伤的促康复均有明显的疗效，HBO促康复疗效稍优于NO。

To study the effects of HBO and NO on brain function under high altitude condition in youth when they returned to sea level fron high altitued. Methods: 24 youth who migrated to sea level from high altitude were tested for WAIS-RC, WMS etc after treatment with HBO and NO. Results: Intelligence and memory increased, and psychological test, such as TEST2.3.3.4 and reactive rate were done better compared with before treatment. The effects of HBO was better than that of NO. Conclusions:HBO and NO could improve significantly the hypoxia-induced disfunction of brain in youth exposed to high altitude for 1 year.