老年高血压患者动脉僵硬度与左心室肥厚关系

Relationship between arterial stiffness and left ventricular hypertrophy in aged patients with essential hypertension

目的探讨老年高血压患者动脉僵硬度与左心室肥厚的关系。方法选择原发性老年高血压患者68例,以左心室重量指数(LVMI)作为评价左心室肥厚指标,将患者分为左心室肥厚组(32例)和非左心室肥厚组(36例)。以颈动脉-股动脉肢体动脉搏动波(cfPWV)和脉压作为评价动脉僵硬度指标,进行24 h动态血压监测、cfPWV及超声心动图检测,并进行多因素相关分析。结果左心室肥厚组较非左心室肥厚组患者cfPWV高[(14.45±1.83)m/s vs(10.89±1.94)m/s]、脉压大[(78.66±9.05)mm Hg(1 mm Hg=0.133 kPa)vs(60.39±7.74)mm Hg],两组比较,差异有统计学意义(P<0.01),logistic回归分析显示,LVMI与cfPWV、脉压呈正相关。结论动脉僵硬度增加是老年高血压患者左心室肥厚的重要危险因素。

Objective To analyse the relationship between arterial stiffness and left ventricular hypertrophy in aged patients with essential hypertension. Methods A total of 68 aged patients with essential hypertension were enrolled. Left ventricular hypertrophy （LVH） was assessed by left ventricular mass index （LVMI） and arterial stiffness was assessed by pulse pressure and carotidfemoral pulse wave velocity （cfPWV）. The subjects were divided into 2 groups： 32 subjects were assigned to the LVH group and 36 subjects were assigned to the group without LVH. All subjects underwent ambulatory blood pressure monitoring, measurement of cfPWV and echocardiography. Results cfPWV and pulse pressure significantly increased in LVH group compared with subjects without LVH[（14.45±1. 83） m/s vs （10. 89±1. 94） m/s,（78. 66 ±9.05） mm Hg vs （60.39±7.74） mm Hg]. LVMI was found to have strong positive correlations with cfPWV and pulse pressure. Conclusion The increase in arterial stiffness is an important risk factor for LVH in aged patients with essential hypertension.