老年人血浆胆红素水平与冠状动脉病变的关系

The relationship between the level of plasma bilirubin and coronary artery disease in the elderly

目的探讨老年人胆红素水平与冠状动脉病变的关系。方法选择疑似冠心病的老年患者132例,根据冠状动脉造影结果分为冠心病组(93例)和对照组(39例),对冠状动脉病变严重程度进行评分,并测定空腹血浆总胆红素、直接胆红素、间接胆红素水平。分析影响冠状动脉病变的相关因素及冠状动脉病变程度与胆红素的关系。结果与对照组比较,冠心病组患者总胆红素和间接胆红素水平明显降低,差异有统计学意义(P<0.05),两组直接胆红素水平比较,差异无统计学意义(P>0.05)。男性、年龄、空腹血糖、高血压和心肌梗死与冠状动脉病变严重程度呈正相关,总胆红素和间接胆红素水平与冠状动脉病变严重程度呈负相关。结论血浆胆红素水平与老年人冠状动脉病变的严重程度呈负相关,其中间接胆红素可能起着更重要的作用。

Objective To explore the relationship between the level of plasma bilirubin and the severity of coronary artery lesion in the elderly. Methods 132 elderly patients were divided into CHD and control groups according to the result of coronary angiography. The levels of TBIL, DBIL and IBIL were measured. The correlative factors of coronary lesion and the relationship between bilirubin and the severity of coronary lesion were analyzed. Results Sex, age, levels of blood glucose and TBIL,history of hypertension and myocardial infarction influenced significantly the severity of coronary artery lesion. The TBIL and IBIL decreased significantly in CHD group compared with control group, with significant difference, but no significant difference in DBIL was seen. There was no significant difference in bilirubin levels between two subgroups divided by age. Conclusion Low level of bilirubin in the elderly significantly influences the severity of coronary artery lesion, and IBIL may be more important than other kinds of bilirubin.