乳腺浸润性小叶癌针吸细胞学诊断探讨

The cytological characteristics of invasive lobular carcinoma of breast by fine needle aspiration cytology

目的探讨经病理组织学证实的乳腺浸润性小叶癌的针吸细胞学特点。方法收集45例经病理组织学证实的乳腺浸润性小叶癌的针吸细胞学涂片,观察细胞学形态特点,并与45例乳腺浸润性导管癌进行对比。结果乳腺浸润性小叶癌的细胞数量较少,以小细胞群为主,单个散在的癌细胞较多,细胞体积小,核及核仁亦小,异型性不明显,多数病例可观察到单个小细胞呈线样或"列兵样"排列。结论通过仔细观察上述细胞学特点可以提高乳腺浸润性小叶癌的针吸细胞学诊断率并有助于分型。

Objective To investigate the cytological characteristics of invasive lobular carcinoma（ILC） of breast by fine needle aspiration cytology （FNAC）. Methods FNAC specimens from 45 cases of invasive lobular carcinoma proved histologically were studied and compared with 45 cases of invasive ductal carcinoma （IDC）. Imaging analysis system was used to evaluate the cell morphology. Results The cytologic characteristics of ILC were as follows： （ 1）The cancer cells of ILC were small, uniform with round nuclei and in conspicuous nucleoli. （2）in the smear, the cells were relativelyfew, single isolated,with more cells. （3）In most of cases, cancer cells were arranged in linear or Indian file pattern. Conclusion The subclassification of ILC can be made with cytological smears in most of cases.