宣肺祛瘀通络中药对慢性阻塞性肺疾病急性加重期血气分析及血浆纤维蛋白原的影响

Effect of Xuanfei Quyu Tongluo Chinese herbal medicine on blood gas analysis and plasma fibrinogen of acute exacerbations of chronic obstructive pulmonary disease

目的探讨宣肺祛瘀通络中药对慢性阻塞性肺疾病(COPD)急性加重期患者血气分析及血浆纤维蛋白原的影响。方法将100例慢性阻塞性肺疾病急性加重期伴有肺动脉高压患者随机分为2组,对照组采取综合治疗方法,治疗组在综合治疗基础上予宣肺祛瘀通络中药治疗。观察2组症状积分;治疗前和治疗后第8d停止吸氧30min后均分别取外周动脉血1mL(肝素抗凝)行血气分析,取静脉血2mL(肝素抗凝)检测血浆纤维蛋白原。结果治疗组治疗后二氧化碳分压[P(CO2)]低于对照组,血氧分压[P(O2)]高于对照组,2组比较差异有统计学意义(P<0.05)。2组治疗后纤维蛋白原水平均较治疗前降低(P<0.05),且2组治疗后比较差异有统计学意义(P<0.05)。治疗组治疗后症状积分与本组治疗前及对照组治疗后比较差异均有统计学意义(P<0.05)。结论宣肺祛瘀通络中药汤剂能够通过降低COPD急性加重期患者血流黏滞度,升高P(O2)水平,降低P(CO2)水平,提高治疗效果。

Objective To explore the effects of Xuanfei Quyu Tangluo decoction on blood gas analysis and plasma fibrinogen in patients with acute exacerbations of chronic obstructive pulmonary disease （COPD）. Methods 100 cases of acute exacerbation of chronic obstructive pulmonary disease with pulmonary hypertension were randomly divided into 2 groups. Cases in the control group were treated by a comprehensive treatment. Patients in the treatment group were treated by combination of a comprehensive treatment and Xuanfei Quyu Tongluo Chinese medicine. Before treatment, after treatment the first stop on the 8th day 30min oxygen are respectively peripheral arterial 1 mL （heparin） line of blood gas analysis, blood taken 2mL （heparin） measured fibrinogen. Result The effective rate in the control group was lower than that in the treatment group. The partial pressure of carbon dioxide [ P（ CO2 ） ] and plasma fibrinogen levels in the treatment group was lower than that in the control group, blood oxygen partial pressure [ P（O2 ） ] in treatment group wan higher than that in control group. There were significant differences between two groups （ P 〈 0.05）. Conclusion Xuanfei Quyu Tongluo decoction can improve effect of acute exacerbation of COPD patients by decreasing blood viscosity and the level of P（ CO2 ）, and increasing the level of P（O2 ）.