红霉素、阿奇霉素序贯疗法治疗小儿支原体肺炎30例

Erythromycin and Azithromycin Sequential Therapy Treatment of 30 Cases of Mycoplasma Pneumonia in Children

目的观察红霉素、阿奇霉素序贯疗法对小儿支原体肺炎的疗效和不良反应。方法把确诊为支原体肺炎患儿随机分为阿奇霉素组、红霉素组及联合治疗组(红霉素、阿奇霉素序贯治疗)共3组,每组30例,对其临床疗效,治疗费用及药物不良反应进行评价。结果3组有效率比较,差异均无显著性(P>0.05)。住院天数、治疗费用以联合治疗组最低,且联合治疗组、阿奇霉素组与红霉素组比较,差异均有显著性(P<0.01)。药物不良反应发生率以联合治疗组、阿奇霉素组为低。联合治疗组、阿奇霉素组与红霉素组不良反应率比较,差异均有显著性(P<0.05)。结论联合治疗组治疗支原体肺炎优于其他两组,同时可减少经济费用,且副作用少。

Objective To observe erythromycin and azithromycin sequential therapy in children with myeoplasma pneumonia and the adverse reactions. Method The children diagnosed with Mycoplasma pneumonia were randomly divided into azithromycin group, erythromycin group and the joint treatment group （erythromycin, azithromyein sequential therapy ） with 30 cases in each group. The clinical efficacy, the cost of treatment and adverse drug reactions were evaluated. Result Comparing the efficacy of three groups there was no significant difference （ P 〉 0.05 ）. The time of hospitalization and treatment cost were minimum in the treat ment group, with significant difference （ P 〈 0.01 ）. The incidence of adverse drug reactions in the treatment group and the azithromycin group was lower than erythromycin group （ P 〈 0.05 ）. Conclusion The joint treatment of mycoplasma pneumonia can reduce the cost and had less side effects.