摘要
目的:观察肠源性内毒素血症对肺脏的影响。方法:复制大鼠肝硬化模型,观察肺功能和形态,支气管肺泡灌洗液中巨噬细胞和中性粒细胞数量以及血气的变化。结果:肝硬化组大鼠氧含量(O2cont)显著降低,肺泡-动脉氧分压差值(AaDO2)明显高于正常,在注射内毒素后差值进一步增大。结论:肺脏是肝硬化时肠源性内毒素血症的重要靶器官,过量内毒素对肺脏的损伤,是肝肺综合征形成的基本机制。
Objective：To observe effect of intestinal endotoxemia（IETM）on the lung. Methods：Reproduce a model of liver cirrhosis in rats. Observe changes of pulmonary functional and morphology, count numbers of macrophage and neutrophilic granulocyte in bronchoalveolar lavage fluid and measure blood gas in rats with liver cirrhosis. Results ： O2 content markedly decreased, difference of O2 partial pressure in alveolar and arterial blood evidently increased in cirrhotic rats. They were further exacerbated in cirrhotic rats after injecting a given dose of endotoxin. Conclusion ： Lung is a target organ of IETM in cirrhosis. A large amount of endotoxin can lead to pulmonary injury, which is a fundamental mechanism in pathogenesis of hepatopulmonary syndrome
出处
《长治医学院学报》
2009年第1期7-10,共4页
Journal of Changzhi Medical College
基金
山西省归国留学人员资助项目(200810)
关键词
肝硬化
内毒素
肝肺综合征
Liver cirrhosis
Endotoxin
Hepatopulmonary syndrome
