IκB激酶-β抑制剂的研究与开发

Research and development of inhibitors of IκB kinase-β

IκB激酶-β(IKK-β)与炎症和肿瘤的发生、发展密切相关。目前,IKK-β抑制剂的研究与开发已成为抗炎、抗肿瘤药物研究的一个新方向。近年来,相继报道了一些新型的合成或天然的IKK-β抑制剂,其中不乏一些高活性且具有药物开发前景的化合物。本文对新报道的IKK-β抑制剂进行了总结,并对这类结构化合物的开发做出展望。

IκB kinase-β（IKK-β） is associated with the development of inflammation and cancer,and it is a new target for curing inflammation and cancer. Among the reported new inhibitors, either synthetic or natural compounds that have high activity and are potentially valuable to explore are found. In this paper,novel IKK-β inhibitors and prospect of research on these compounds are summarized.