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趋化性细胞因子CCL28的功能与表达 被引量：4

Function and expression of chemokine CCL28
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摘要 CCL28是新近发现的趋化性细胞因子家族CC类中的成员。多种粘膜组织的上皮细胞可以产生CCL28，其受体为CCR10和CCR3。通过与相应受体结合，CCL28可介导血循环中的CD4^＋T细胞、CD8^＋T细胞、IgA抗体分泌细胞（ASC）等免疫活性细胞归巢迁徙至相关组织；另外，CCL28还具有明显的广谱抗微生物活性。因而，在粘膜免疫及某些肿瘤的免疫中，CCL28发挥着重要作用。CCL28的表达受到多种内外因素的影响。对其表达调节机制的阐明，必将为相关疾病的防治研究提供新的思路。 CCL28 is a novel cysteine-cysteine（CC） chemokine, which is selectively expressed by epithelial cells in diverse mucosal tissues. The receptors of this chemokine are CCR10 and CCR3. By binding CCR10 or CCR3, CCL28 recruits CD4^＋T cells, CD8^＋T cells and IgA^＋ ASC（ antibody-secreting cell） from blood to related tissues. Furthermore, CCL28 has potent antimicrobial activity. Therefore, CCL28 may play important roles in mucosal and tumor immunity. The expression of CCL28 may be influenced by several exterior and interior factors. Investigation on its expression regulation may set light on exploring a new way for the prevention and treatment of related diseases.
作者 刘雪 姜广水
机构地区 山东大学口腔医学院口腔内科学研究所 不详
出处 《国际免疫学杂志》 CAS 北大核心 2009年第2期103-106,共4页 International Journal of Immunology
基金 国家自然科学基金资助项目（30171010,303713） 山东省自然基金项目（Y2006c124）
关键词 CCL28 趋化性细胞因子 IgA抗体分泌细胞 CCR10 CCR3 CCL28 Chemokine IgA^＋ASC CCR10 CCR3
分类号 R392.1 [医药卫生—免疫学]
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参考文献20

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共引文献4

同被引文献50

  • 1孙建,李延青,陈建,吕翠霞,左秀丽,郭玉亭,张海燕,赵宪邨.肠易激综合症的心理检测及对应治疗[J].中华腹部疾病杂志,2003,3(1):19-20. 被引量：16
  • 2包军,徐沪济.趋化因子和类风湿关节炎[J].临床内科杂志,2006,23(8):574-576. 被引量：5
  • 3李潇,郑燕,李冬,姜广水.人唾液CCL28与sIgA抗体分泌的相关性研究[J].山东大学学报（医学版）,2007,45(1):65-67. 被引量：1
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引证文献4

二级引证文献22

国际免疫学杂志
2009年 第2期

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