Th1／Th2在慢性乙型、丙型肝炎中的作用

Roles of Th1/Th2 in chronic hepatitis B and chronic hepatitis C

病毒性肝炎的发病及转归与细胞免疫机制有很密切的关系。辅助性T细胞（Th）是体内一类重要的调节细胞，根据其产生细胞因子的不同分为Th1和Th2亚型，分别参与调节细胞免疫和体液免疫。Th1和Th2细胞在病毒性肝炎中发挥重要作用，Th1／Th2失衡引起病毒性肝炎慢性化。采用单种细胞因子纠正Th1／Th2失衡方法在慢性乙型、丙型肝炎临床治疗中的研究进展，为治疗慢性病毒性肝炎提供了新思路。

There is a close relationship between the onset and prognosis of viral hepatitis and cell immune mechanisms.T helper Cells is one of an important kind of immune modulation ceils. According to the its production of cytokines ,T helper cells can be divided into two subgroups, Th1 and Th2, which participate in the modulation of cell and humoral immune, respectively. Thl and Th2 play a key role in viral hepatitis. The imbalance between Th1 and Th2 can result in chronic viral hepatitis. In order to provide new insight for the treatment of chronic viral hepatitis, We reviewed Th1/Th2 and their related eytokines in hepatitis B and hepatitis C clinical trials were and the treatment of progress of using single cytokine to correct Th1/Th2 in the chronic hepatitis B and hepatitis C.