p53、Bcl-2表达与非小细胞肺癌放射治疗预后的相关分析

Relationship between the expression of p53 and Bcl-2 protein and prognosis of non-small cell lung cancer undergone radiation therapy

目的：探讨p53与Bcl-2基因表达与非小细胞肺癌放射治疗预后的关系。方法：回顾性分析58例接受单纯性放射治疗（15mv，dt=66～68Gy／33～34f／45～49d。SSD=100cm，剂量率为2Gy）的非小细胞肺癌肺癌的患者的生存时间与p53、Bcl-2表达的相关关系，应用SPSS10．0软件进行kaplan-meier生存分析，并用log-rank法进行检验，进一步应用COX-regression进行多因素分析。结果：p53、Bcl-2的表达与非小细胞肺癌放疗预后呈负相关关系。结论：p53、Bcl-2是预测非小细胞肺癌患者放射治疗预后有意义的临床指标。

Objective：to study the expression of p53 , Bcl-2 in the non-small cell lung cancer and the relationship be- tween the expression and the prognosis. Methods ：streptavidin-peroxidase （s-p）immunohistochemistry （IHC）method was used to detect the p53 protein and Bcl-2 protein in primary non-small cell lung cancer tissues.SPSS10.0 software was used to produce kaplan-meier survival analysis, draw survival curve, and log-rank test was applied to determine if there is a relationship between the expression of p53 and Bcl-2 and prognosis,using cox-regression,make a further confirmation if the expression of p53 and Bcl-2 are independent prognosis factors. Results：The positive expression of p53 and Bcl-2 are indepenprognosis of non-small cell lung cancer undergone radiation therapy（P=0.019）.Conclusion：It is meaning-ful to test p53,Bcl-2.