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糖心通对STZ高脂糖尿病模型大鼠TXB_2、6-keto-PGF1α、PAI-1水平的影响 被引量：1

The tangxintong particles' efficacy of the STZ-diabetic high-fat rats' TXB_2、6-keto-PGF1α and PAI-1
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摘要 目的:观察糖心通对STZ高脂糖尿病模型大鼠TXB2、6-keto-PGF1α、PAI-1水平的影响。方法:以腹腔注射链脲佐菌素(STZ)并辅以高脂饮食喂养造成STZ高脂糖尿病模型大鼠,观察糖心通对大鼠血栓烷素B2(TXB2)、6-酮-前列腺素1α(6-keto-PGF1α)、纤溶酶原激活物抑制剂-1(PAI-1)的影响。结果:糖心通能显著降低糖尿病大鼠血浆TXB2水平,并升高血浆6-Keto-PGFlα水平,同时降低血清PAI-1水平。与对照组相比,有显著性差异(P<0.05)。结论:糖心通具有较好的保护血管内皮功能的作用。 Objective：To observe the Tangxintong particles＇ efficacy of laboratory animals＇ TXB2,6-keto-PGF1α,PAI-1 level. Methods： We established the High-fat diabetic rat models by intraperitoneal injection of streptozotocin （STZ） and feeding high-fat diet to the rats. Then we observe the Tangxintong particles＇ impact of TXB2,6-keto-PGF1α,PAI-1 level. Results： The Tangxintong particles can reduce the level of plasma TXB2 of diabetic rats significantly,increase plasma 6-Keto-PGF1α level and reduce PAI-1 level of serum. Conclusion： The Tangxintong particles have good protective function to blood vessel bast function.
作者 钱秋海 刘大文 赵懿 扈东兵 陈文辉 钱卫斌
机构地区 山东中医药大学附属医院 山东中医药大学临床学院
出处 《中国当代医药》 2009年第5期18-20,共3页 China Modern Medicine
关键词 糖心通 血管内皮功能 The Tangxintong particles Blood vessel bast function
分类号 R781.64 [医药卫生—口腔医学]
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参考文献10

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同被引文献9

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  • 8钱秋海,乔培佐,刘大文,赵懿,钱卫斌.糖心通对糖尿病性心脏病的保护性机制临床研究[J].中国医药导刊,2009,11(1):37-39. 被引量：2
  • 9司晓晨,尚文斌,卞慧敏,程海波.链脲佐菌素加高脂膳食诱导2型糖尿病大鼠模型[J].安徽中医临床杂志,2003,15(5):383-385. 被引量：84

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中国当代医药
2009年 第5期

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