摘要
目的:建立离子选择性电极法测定卡托普利片含量的新方法。方法:卡托普利结构含有-SH,呈酸性,与碱作用生成RS-硫离子选择性电极对其产生响应。结果:电极响应的电位值与-lg[RS-]符合能斯特方程。能斯特响应范围为1.0×10-6～1.0×10-2mol/L(r=0.9998).平均回收率为99.4%,RSD=0.29%(n=6)。结论:本法设备仪器简单,分析快速,专属性强。
Objective： A new method was established for the determination of Captopril with ion selective electrode. Methods： Based on the thiohydroxy group （-SH） in Captopril can rect with base and produce RS-,Results： The linear relationship between E and - lg[RS-] was held in the range of 1.0×10^-6～1.0×10^-2mol/L（r=0.9998）.The average recovery was 99.4% ,RSD=0.29%（n=6）. Conclusion：This method is simple,convenient,specific and is suitable for the quality control of Captopril tablets.
出处
《中国当代医药》
2009年第5期33-34,共2页
China Modern Medicine
